Recent guideline from ISH says for treatment of hypertension any drug that the patient can take and afford is OK. But In last few years the atenolol has been projected as villain, so most doctors have started moving away from… Read the rest
Aliskiren is a direct renin inhibitor, combining this with ACE and ARBs, block s RAS completely. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE) study investigated the effects of Aliskiren in addition to ACE inhibitor or ARB… Read the rest
Autophagy is cellular survival mechanism during starvation, by Autophagy cells get their energy from lysosomal degradation of its own cellular components. This mechanism is seen more commonly seen in cancer cells. In pulmonary arterial hypertension (PAH), Pulmonary Artery Smooth Muscle… Read the rest
Levosimendan, a myofilament Ca2+ sensitizer, increases myocardial contractility without increase in oxygen demand. Apart from inotropic effects Levosimendan also has vasodilator effects, by stimulation of adenosine triphosphate–dependent potassium channels.
REVIVE I and II are sequential trials, hypothesis was tested in … Read the rest
RE-LY trial showed dabigatran 110mg bid was associated with decreased bleeding risk and similar efficacy as warfarin in preventing theombo-embolic events in non valvular AF and at dose 150 mg bid of dabigatran was associated with similar bleeding risk (for… Read the rest